Prednisolone Sodium Phosphate
Modify Date: 2024-01-02 23:29:14
Prednisolone Sodium Phosphate structure
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Common Name | Prednisolone Sodium Phosphate | ||
|---|---|---|---|---|
| CAS Number | 125-02-0 | Molecular Weight | 484.388 | |
| Density | N/A | Boiling Point | 100 °C | |
| Molecular Formula | C21H27Na2O8P | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 361.9ºC | |
Use of Prednisolone Sodium PhosphatePrednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2]. |
| Name | Prednisolone phosphate sodium |
|---|---|
| Synonym | More Synonyms |
| Description | Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid ReceptorPrednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2]. |
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| Related Catalog | |
| References |
| Boiling Point | 100 °C |
|---|---|
| Molecular Formula | C21H27Na2O8P |
| Molecular Weight | 484.388 |
| Flash Point | 361.9ºC |
| Exact Mass | 484.123901 |
| PSA | 156.83000 |
| LogP | 2.55100 |
| Vapour Pressure | 4.17E-21mmHg at 25°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xi |
|---|---|
| Risk Phrases | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2937229000 |
| HS Code | 2937229000 |
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| (11beta) |
| Phortisolone |
| disodium 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl phosphate |
| Inflamase |
| prednisolon disodium phosphate |
| Prednisolone sodium phosphate |
| Optival |
| Predsol |
| Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11β)- |
| 11b,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(Disodium phosphate) |
| Codelsol |
| Prednisolone (disodium phosphate) |
| prednisolone 21-disodium phosphate |
| Prednisolone 21-Phosphate Disodium Salt |
| MFCD07776968 |
| 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate) |
| phosphate de 2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle de disodium |
| METRETON |
| Prozorin |
| Disodium Prednisolone 21-Phosphate |
| EINECS 204-722-9 |
| Solucort |
| Dinatrium-2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylphosphat |
| Predsolan |
| Prednesol |
| Dojilon |
| Pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, sodium salt, (11β)- (1:2) |
| Disodium (11β)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl phosphate |
| Ak-pred |