AI-10-49
Modify Date: 2024-01-11 10:43:31
AI-10-49 structure
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Common Name | AI-10-49 | ||
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| CAS Number | 1256094-72-0 | Molecular Weight | 660.523 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 790.3±70.0 °C at 760 mmHg | |
| Molecular Formula | C30H22F6N6O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 431.8±35.7 °C | |
Use of AI-10-49AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.IC50 value: 0.26 uM [1]Target: CBFβ-SMMHC/RUNX1 interaction inhibitorAI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics,and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML, and they provide support for transcription factor targeted therapy in other cancers. |
| Name | 2,2'-[Oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-1H-benzimidazole] |
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| Synonym | More Synonyms |
| Description | AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.IC50 value: 0.26 uM [1]Target: CBFβ-SMMHC/RUNX1 interaction inhibitorAI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics,and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML, and they provide support for transcription factor targeted therapy in other cancers. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 790.3±70.0 °C at 760 mmHg |
| Molecular Formula | C30H22F6N6O5 |
| Molecular Weight | 660.523 |
| Flash Point | 431.8±35.7 °C |
| Exact Mass | 660.155579 |
| PSA | 129.29000 |
| LogP | 7.00 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.611 |
| Storage condition | -20℃ |
| AI-10-49 |
| 1H-Benzimidazole, 2,2'-[oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[5-(trifluoromethoxy)- |
| 2,2'-[Oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[5-(trifluoromethoxy)-1H-benzimidazole] |