Ro 41-0960

Modify Date: 2024-01-02 23:14:40

Ro 41-0960 Structure
Ro 41-0960 structure
Common Name Ro 41-0960
CAS Number 125628-97-9 Molecular Weight 277.20500
Density 1.536g/cm3 Boiling Point 489.9ºC at 760 mmHg
Molecular Formula C13H8FNO5 Melting Point N/A
MSDS Chinese USA Flash Point 250.1ºC

 Use of Ro 41-0960


Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].

 Names

Name (3,4-dihydroxy-5-nitrophenyl)-(2-fluorophenyl)methanone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.536g/cm3
Boiling Point 489.9ºC at 760 mmHg
Molecular Formula C13H8FNO5
Molecular Weight 277.20500
Flash Point 250.1ºC
Exact Mass 277.03900
PSA 103.35000
LogP 2.89930
Vapour Pressure 3.2E-10mmHg at 25°C
Index of Refraction 1.656

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PC4952300
CHEMICAL NAME :
Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-
CAS REGISTRY NUMBER :
125628-97-9
LAST UPDATED :
199509
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H8-F-N-O5
MOLECULAR WEIGHT :
277.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
312 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS PC4952300

 Articles25

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Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue.

Am. J. Physiol. Heart Circ. Physiol. 309 , H1904-14, (2015)

Perivascular adipose tissue (PVAT) reduces vasoconstriction to norepinephrine (NE). A mechanism by which PVAT could function to reduce vascular contraction is by decreasing the amount of NE to which t...

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

J. Biol. Chem. 290 , 13992-4003, (2015)

Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by Na(+)-dependent reuptake of released neurotransmitters. Previous studies suggested that Na(+)-binding reconfigures dynamically ...

Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E2production by human fetal membranes

Am. J. Obstet. Gynecol. 201(5) , 496.e1-7, (2009)

Objective The purpose of this study was to evaluate the expression and function of catechol-O-methyltransferase in human fetal membranes at term.

 Synonyms

OR 1139
3,4-dihydroxy-5-nitrophenyl 2-fluorophenyl ketone
(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone
2'-fluoro-3,4-dihydroxy-5-nitrobenzophenone
3,4-dihydroxy-5-nitro-2'-fluorobenzophenone
Ro 41-0960
2'-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
Methanone,(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)
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