JP1302 dihydrochloride

Modify Date: 2024-01-16 00:55:01

JP1302 dihydrochloride Structure
JP1302 dihydrochloride structure
Common Name JP1302 dihydrochloride
CAS Number 1259314-65-2 Molecular Weight 441.40
Density N/A Boiling Point N/A
Molecular Formula C24H26Cl2N4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JP1302 dihydrochloride


JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM[1][2].

 Names

Name N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
Synonym More Synonyms

 JP1302 dihydrochloride Biological Activity

Description JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM[1][2].
Related Catalog
Target

Ki: 28 nM (α2C- adrenoceptor)[2]. Kb: 16 nM (α2C- adrenoceptor)[2].

References

[1]. Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2.

[2]. Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402.

 Chemical & Physical Properties

Molecular Formula C24H26Cl2N4
Molecular Weight 441.40
Exact Mass 440.153442

 Synonyms

N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
N-[4-(4-Methylpiperazin-1-yl)phenyl]acridin-9-amine dihydrochloride
9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-, hydrochloride (1:2)
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