JCP174

Modify Date: 2024-01-06 12:21:28

JCP174 structure	Common Name	JCP174
	CAS Number	126062-19-9	Molecular Weight	253.682
	Density	1.4±0.1 g/cm3	Boiling Point	463.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₂ClNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	234.1±28.7 °C

Use of JCP174

JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].

Name	7-Amino-4-chloro-3-propoxy-isocoumarin
Synonym	More Synonyms

Description	JCP174 is an inhibitor of palmitoyl protein thioesterase-1 (TgPPT1), a depalmitoylase in the parasite T. gondii[1]. JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase
References	[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6. [2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18. [3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase

References

[1]. Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6.

[2]. Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18.

[3]. Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.

Density	1.4±0.1 g/cm3
Boiling Point	463.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₂ClNO₃
Molecular Weight	253.682
Flash Point	234.1±28.7 °C
Exact Mass	253.050568
LogP	2.10
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.601

7-Amino-4-chloro-3-propoxy-isocoumarin

MFCD22378306

1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-propoxy-

7-Amino-4-chloro-3-propoxy-1H-isochromen-1-one

JCP174

Use of JCP174

Names

JCP174 Biological Activity

Chemical & Physical Properties

Synonyms