Amiodarone-d10 hydrochloride

Modify Date: 2024-01-12 18:35:09

Amiodarone-d10 hydrochloride Structure
Amiodarone-d10 hydrochloride structure
Common Name Amiodarone-d10 hydrochloride
CAS Number 1261393-77-4 Molecular Weight 691.83
Density N/A Boiling Point N/A
Molecular Formula C25H20D10ClI2NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amiodarone-d10 hydrochloride


Amiodarone-d10 hydrochloride is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].

 Names

Name Amiodarone-d10 hydrochloride

 Amiodarone-d10 hydrochloride Biological Activity

Description Amiodarone-d10 hydrochloride is the deuterium labeled Amiodarone. Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67.

[3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

 Chemical & Physical Properties

Molecular Formula C25H20D10ClI2NO3
Molecular Weight 691.83
Storage condition 2-8°C