NH2-Ph-C4-acid-NH2-Me

Modify Date: 2024-01-11 00:13:02

NH2-Ph-C4-acid-NH2-Me Structure
NH2-Ph-C4-acid-NH2-Me structure
Common Name NH2-Ph-C4-acid-NH2-Me
CAS Number 1263819-48-2 Molecular Weight 222.28
Density N/A Boiling Point N/A
Molecular Formula C12H18N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of NH2-Ph-C4-acid-NH2-Me


PROTAC Linker 31 is a PROTAC linker, which refers to the Alkyl-Chain composition. PROTAC Linker 31 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name PROTAC Linker 31

 NH2-Ph-C4-acid-NH2-Me Biological Activity

Description PROTAC Linker 31 is a PROTAC linker, which refers to the Alkyl-Chain composition. PROTAC Linker 31 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl-Chain

References

[1]. Leverett CA, et al. Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads. ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004.

 Chemical & Physical Properties

Molecular Formula C12H18N2O2
Molecular Weight 222.28
Storage condition 2-8°C