sulfamerazine sodium

Modify Date: 2024-01-04 14:40:57

sulfamerazine sodium structure	Common Name	sulfamerazine sodium
	CAS Number	127-58-2	Molecular Weight	286.285
	Density	N/A	Boiling Point	519.1ºC at 760mmHg
	Molecular Formula	C₁₁H₁₁N₄NaO₂S	Melting Point	216-219 °C
	MSDS	Chinese USA	Flash Point	267.8ºC
	Symbol	GHS07	Signal Word	Warning

Use of sulfamerazine sodium

Sulfamerazine Sodium is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1].

Name	sodium,(4-aminophenyl)sulfonyl-(4-methylpyrimidin-2-yl)azanide
Synonym	More Synonyms

Description	Sulfamerazine Sodium is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1].
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131.

Boiling Point	519.1ºC at 760mmHg
Melting Point	216-219 °C
Molecular Formula	C₁₁H₁₁N₄NaO₂S
Molecular Weight	286.285
Flash Point	267.8ºC
Exact Mass	286.050049
PSA	97.56000
LogP	2.68880
Vapour Pressure	7.03E-11mmHg at 25°C
Storage condition	2-8℃

sulfamerazine sodium MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP0760000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-, monosodium salt

CAS REGISTRY NUMBER :: 127-58-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C11-H11-N4-O2-S.Na

MOLECULAR WEIGHT :: 286.31

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ& D1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1522 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1739 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H332
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/22
Safety Phrases	S7-S24-S45
RIDADR	NONH for all modes of transport
WGK Germany	3

EINECS 204-851-0

Sulfamerazin natrium

Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, sodium salt (1:1)

MFCD00068332

Sodium [(4-aminophenyl)sulfonyl](4-methyl-2-pyrimidinyl)azanide

2-Sulfanilamido-4-methylpyrimidine sodium salt

Solumedine

UNII-JOV4UJY07O

Solfamerazina sodica [DCIT]

Sodium sulfamerazine

sulfamerazine sodium

Soluble sulfamerazine

Sodium sulphamerazine

Sodium [(4-aminophenyl)sulfonyl](4-methylpyrimidin-2-yl)azanide

Sulfamerazine sodium salt

Sulfamerazine (sodium salt)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: sulfamerazine sodium
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sulfamerazine sodium
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sulfamerazine sodium
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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sulfamerazine sodium

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