p-SCN-Bn-DOTA

Modify Date: 2024-01-07 17:35:14

p-SCN-Bn-DOTA Structure
p-SCN-Bn-DOTA structure
Common Name p-SCN-Bn-DOTA
CAS Number 127985-74-4 Molecular Weight 551.61
Density N/A Boiling Point N/A
Molecular Formula C24H33N5O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of p-SCN-Bn-DOTA


p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunotherapy of tumor[1][2].

 Names

Name 2-[4,7,10-tris(carboxymethyl)-6-[(4-isothiocyanatophenyl)methyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
Synonym More Synonyms

 p-SCN-Bn-DOTA Biological Activity

Description p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunotherapy of tumor[1][2].
Related Catalog
In Vitro p-SCN-Bn-DOTA is complexed with 5 different metal ions: In(III), Y(III), Lu(III), Gd(III) and Cu(II)[2].
References

[1]. Vera DRB, et, al. Preclinical evaluation of (177)lu-nimotuzumab: a potential tool for radioimmunotherapy of epidermal growth factor receptor-overexpressing tumors. Cancer Biother Radiopharm. 2011 Jun;26(3):287-97.

[2]. Giannini G, et, al. Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors. Bioorg Med Chem. 2019 Aug 1;27(15):3248-3253.

 Chemical & Physical Properties

Molecular Formula C24H33N5O8S
Molecular Weight 551.61
Exact Mass 551.20500
PSA 206.61000

 Synonyms

UNII-13KT123BYW
2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
cDOTA-Bnz-NCS
p-isothiocyanatobenzyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid,2-((4-isothiocyanatophenyl)methyl)
2-(p-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraaceticacid
p-SCN-Bz-DOTA
p-SCN-Bn-DOTA
2-(p-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
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