Hydroxypropyl-β-cyclodextrin

Modify Date: 2024-01-02 00:35:54

Hydroxypropyl-β-cyclodextrin structure	Common Name	Hydroxypropyl-β-cyclodextrin
	CAS Number	128446-35-5	Molecular Weight	1541.538
	Density	1.4±0.1 g/cm3	Boiling Point	1521.9±60.0 °C at 760 mmHg
	Molecular Formula	C₆₃H₁₁₂O₄₂	Melting Point	278ºC (dec.)
	MSDS	Chinese USA	Flash Point	874.2±32.9 °C

Use of Hydroxypropyl-β-cyclodextrin

(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.

Name	(2-Hydroxypropyl)-β-cyclodextrin
Synonym	More Synonyms

Description	(2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer
In Vitro	Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin[2].
In Vivo	(2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[1]. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects[2].
Cell Assay	Cells are incubated with (2-Hydroxypropyl)-β-cyclodextrin at various concentrations (5, 7.5, 10, 15, 20 mM) for 72 hours. Cell viability is assessed using a trypan blue dye exclusion method and cell proliferation is evaluated using a modified methyl-thiazol-diphenyl- tetrazolium (MTT) assay[2].
Animal Admin	Mice: Mice are intraperitoneally injected with 200 μL vehicle (saline) or (2-Hydroxypropyl)-β-cyclodextrin (50 or 150 mM) for 20 consecutive days 3 days after transplantation, and survival is monitored daily. Leukemic cell engraftment is confirmed by detection of GFP-positive cells in the recipient’s BM using flow cytometry[2].
References	[1]. Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22. [2]. Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946.

Density	1.4±0.1 g/cm3
Boiling Point	1521.9±60.0 °C at 760 mmHg
Melting Point	278ºC (dec.)
Molecular Formula	C₆₃H₁₁₂O₄₂
Molecular Weight	1541.538
Flash Point	874.2±32.9 °C
Exact Mass	1540.662842
PSA	618.66000
LogP	-6.23
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.545
Storage condition	2-8°C
Water Solubility	H2O: 45 % (w/v) \| Soluble in water.

Hydroxypropyl-β-cyclodextrin MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GU2293332

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(2-Hydroxypropyl)-Beta-Cyclodextrin

EINECS 420-920-1

MFCD00069372

Hydroxypropyl-beta-cyclodextrin

(2-HYDROXYPROPYL)-β-CYCLODEXTRIN

(2-Hydroxypropyl)-Beta-Cyclodextri

Hydroxypropyl-β-cyclodextrin