Seltorexant hydrochloride
Modify Date: 2024-01-13 15:51:48
Seltorexant hydrochloride structure
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Common Name | Seltorexant hydrochloride | ||
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| CAS Number | 1293284-49-7 | Molecular Weight | 443.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23ClFN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Seltorexant hydrochlorideSeltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1]. |
| Name | Seltorexant hydrochloride |
|---|
| Description | Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1]. |
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| Related Catalog | |
| Target |
human OX2R:8.0 (pKi) rat OX2R:8.1 (pKi) |
| In Vivo | Seltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats[1]. The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats[1]. Animal Model: Male Sprague-Dawley rats (350-450 g)[1] Dosage: 30 mg/kg Administration: p.o.; per day for 7 days Result: The reduced sleep onset (non–rapid eye movement (NREM) latency) and the increased NREM sleep duration were maintained upon 7-day repeated dosing with JNJ-42847922. The prolongation of NREM sleep time was due to a significant increase in NREM bout duration throughout the treatment period assessed on D1 and D7. Rapid eye movement (REM) sleep was only marginally affected on D4 of treatment, resulting in a small but significant reduction in REM sleep latency and an increase in REM sleep duration. |
| References |
| Molecular Formula | C21H23ClFN7O |
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| Molecular Weight | 443.91 |