PD 135158

Modify Date: 2024-01-28 06:59:21

PD 135158 structure	Common Name	PD 135158
	CAS Number	130325-35-8	Molecular Weight	811.96
	Density	N/A	Boiling Point	860.3ºC at 760 mmHg
	Molecular Formula	C₄₂H₆₁N₅O₁₁	Melting Point	N/A
	MSDS	N/A	Flash Point	474.1ºC

Use of PD 135158

PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1].

Name	1-deoxy-1-(methylamino)
Synonym	More Synonyms

Description	PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Neurological Disease
Target	CCKBR:2.8 nM (IC50) CCKAR:1232 nM (IC50)
In Vivo	PD 135158 (CAM 1028; 0.001-0.1 mg/kg; s.c.; once) 增强大鼠的潜在抑制作用，显示出抗精神病潜能[2]。 Animal Model: Male Sprague-Dawley rats, conditioned suppression of drinking procedure model[2] Dosage: 0.001, 0. 01, and 0.1 mg/kg Administration: 0.2 mL/kg SC 30 min before prexposure and conditioning Result: Elicited a clear latent inhibition effect under conditions that did not lead to latent inhibition in control rats.
References	[1]. Hughes J, et al. Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6728-32. [2]. Gracey DJ, et al. PD-135,158, a cholecystokinin(B) antagonist, enhances latent inhibition in the rat. Pharmacol Biochem Behav. 2000 Mar;65(3):459-63.

Boiling Point	860.3ºC at 760 mmHg
Molecular Formula	C₄₂H₆₁N₅O₁₁
Molecular Weight	811.96
Flash Point	474.1ºC
Exact Mass	616.32600
PSA	149.62000
LogP	6.42130
Vapour Pressure	1.51E-31mmHg at 25°C

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PD 135158
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Cam 1028
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Cam 1028
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PD 135158
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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