![]() PD 135158 structure
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Common Name | PD 135158 | ||
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CAS Number | 130325-35-8 | Molecular Weight | 811.96 | |
Density | N/A | Boiling Point | 860.3ºC at 760 mmHg | |
Molecular Formula | C42H61N5O11 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 474.1ºC |
Use of PD 135158PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1]. |
Name | 1-deoxy-1-(methylamino) |
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Synonym | More Synonyms |
Description | PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. PD 135158 shows anxiolytic activity[1]. |
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Related Catalog | |
Target |
CCKBR:2.8 nM (IC50) CCKAR:1232 nM (IC50) |
In Vivo | PD 135158 (CAM 1028; 0.001-0.1 mg/kg; s.c.; once) 增强大鼠的潜在抑制作用,显示出抗精神病潜能[2]。 Animal Model: Male Sprague-Dawley rats, conditioned suppression of drinking procedure model[2] Dosage: 0.001, 0. 01, and 0.1 mg/kg Administration: 0.2 mL/kg SC 30 min before prexposure and conditioning Result: Elicited a clear latent inhibition effect under conditions that did not lead to latent inhibition in control rats. |
References |
Boiling Point | 860.3ºC at 760 mmHg |
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Molecular Formula | C42H61N5O11 |
Molecular Weight | 811.96 |
Flash Point | 474.1ºC |
Exact Mass | 616.32600 |
PSA | 149.62000 |
LogP | 6.42130 |
Vapour Pressure | 1.51E-31mmHg at 25°C |
car011 |