KHK-IN-1

Modify Date: 2024-01-11 20:38:14

Use of KHK-IN-1

KHK-IN-1 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM; interacts with Asp-27B in the ATP-binding region of KHK.

Name	KHK-IN-1
Synonym	More Synonyms

Description	KHK-IN-1 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM; interacts with Asp-27B in the ATP-binding region of KHK.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Maryanoff BE, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9. [2]. Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.

Description

KHK-IN-1 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM; interacts with Asp-27B in the ATP-binding region of KHK.

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

Pyrimido[5,4-d]pyrimidine-4,8-diamine, N8-(cyclopropylmethyl)-N4-[2-(methylthio)phenyl]-2-(1-piperazinyl)-

N8-(Cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(1-piperazinyl)pyrimido[5,4-d]pyrimidine-4,8-diamine

N8-(Cyclopropylmethyl)-N4-[2-(Methylsulfanyl)phenyl]-2-(Piperazin-1-Yl)pyrimido[5,4-D]pyrimidine-4,8-Diamine

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Price: $420/5mg

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