Exendin-3 trifluoroacetate salt
Exendin-3 trifluoroacetate salt structure
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Common Name | Exendin-3 trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 130357-25-4 | Molecular Weight | 4202.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C184H282N50O61S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Exendin-3 trifluoroacetate saltExendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn . |
| Name | EXENDIN-3 |
|---|---|
| Synonym | More Synonyms |
| Description | Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn . |
|---|---|
| Related Catalog | |
| Target |
VIP receptor, putative exendin receptor[1] |
| In Vitro | Exendin-3 interacts with at least two receptors on guinea pig pancreatic acini; at high concentrations (>100 nM) the peptide interacts with VIP receptors, thereby causing a large increase in cAMP and stimulating amylase release; at lower concentrations (0.1-3 nM) the peptide interacts with a putative exendin receptor, thereby causing a smaller increase in cAMP of undetermined function[1]. |
| Kinase Assay | Effect of increasing concentrations of two VIP receptor antagonists on the increase in amylase release are observed with VIP, secretin, or exendin-3. Male Hartley guinea pigs Acini were incubated with VIP (1 nM), secretin (1 μM), or Exendin-3 (1 μM) for 30 min at 37°C, alone or in combination with indicated concentrations of [AcTyr, D-Phe]GRF 1-29 amide (solid symbols) or [4-Cl-D-Phe,Leu] VIP (open symbols)[1]. |
| References |
| Molecular Formula | C184H282N50O61S |
|---|---|
| Molecular Weight | 4202.57 |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.
J. Biol. Chem. 267 , 7402, (1992) The recent identification in Heloderma horridum venom of exendin-3, a new member of the glucagon superfamily that acts as a pancreatic secretagogue, prompted a search for a similar peptide in Heloderm... |
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Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.
J. Clin. Invest. 101 , 1334-1341, (1998) To examine the influence of the putative satiety factor (GLP-1) on the hypothalamo-pituitary-gonadal axis, we used GT1-7 cells as a model of neuronal luteinizing hormone- releasing hormone (LHRH) rele... |
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Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.
Diabetes 55(12) , 3463-9, (2006) In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GL... |
| MFCD00240170 |
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