RP-001

Modify Date: 2024-02-06 18:15:22

RP-001 structure	Common Name	RP-001
	CAS Number	1306761-53-4	Molecular Weight	468.93300
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RP-001

RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

Name	N-{4-[5-(3-Cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-di hydro-1H-inden-1-yl}-β-alanine hydrochloride (1:1)

Description	RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Neurological Disease
In Vitro	RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels[1].
In Vivo	RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].
References	[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6.

Molecular Formula	C₂₄H₂₄N₄O₄
Molecular Weight	468.93300
Exact Mass	468.15600
PSA	121.27000
LogP	5.30698

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: RP-001
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Rp-001 Hydrochloride
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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