RP-001
Modify Date: 2024-02-06 18:15:22
RP-001 structure
|
Common Name | RP-001 | ||
|---|---|---|---|---|
| CAS Number | 1306761-53-4 | Molecular Weight | 468.93300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H24N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RP-001RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1]. |
| Name | N-{4-[5-(3-Cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-di hydro-1H-inden-1-yl}-β-alanine hydrochloride (1:1) |
|---|
| Description | RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1]. |
|---|---|
| Related Catalog | |
| In Vitro | RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels[1]. |
| In Vivo | RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1]. |
| References |
| Molecular Formula | C24H24N4O4 |
|---|---|
| Molecular Weight | 468.93300 |
| Exact Mass | 468.15600 |
| PSA | 121.27000 |
| LogP | 5.30698 |