4,9-Anhydrotetrodotoxin

Modify Date: 2024-01-06 14:04:04

4,9-Anhydrotetrodotoxin Structure
4,9-Anhydrotetrodotoxin structure
 Common Name 4,9-Anhydrotetrodotoxin
CAS Number 13072-89-4 Molecular Weight 206.24100
Density 3.07g/cm3 Boiling Point 725.6ºC at 760mmHg
Molecular Formula C11H14N2O2 Melting Point N/A
MSDS N/A Flash Point 392.6ºC

 Use of 4,9-Anhydrotetrodotoxin


4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].

 Names

Name (4R)-4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one
Synonym More Synonyms

 4,9-Anhydrotetrodotoxin Biological Activity

Description 4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].
Related Catalog
In Vitro 4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].
References

[1]. Nicholas Denomme, et al. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neurosci Lett. 2020 Apr 17;724:134853.  

 Chemical & Physical Properties

Density 3.07g/cm3
Boiling Point 725.6ºC at 760mmHg
Molecular Formula C11H14N2O2
Molecular Weight 206.24100
Flash Point 392.6ºC
Exact Mass 206.10600
PSA 56.06000
LogP 0.87730
Vapour Pressure 2.63E-24mmHg at 25°C
Index of Refraction 2.298

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

Anhydro-epitetrodotoxin
anhydrotetrodotoxin
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Chemsrc provides 4,9-Anhydrotetrodotoxin(CAS#:13072-89-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 4,9-Anhydrotetrodotoxin are included as well.>> amp version: 4,9-Anhydrotetrodotoxin

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