4,9-Anhydrotetrodotoxin

Modify Date: 2024-01-06 14:04:04

4,9-Anhydrotetrodotoxin structure	Common Name	4,9-Anhydrotetrodotoxin
	CAS Number	13072-89-4	Molecular Weight	206.24100
	Density	3.07g/cm3	Boiling Point	725.6ºC at 760mmHg
	Molecular Formula	C₁₁H₁₄N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	392.6ºC

Use of 4,9-Anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].

Name	(4R)-4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one
Synonym	More Synonyms

Description	4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
In Vitro	4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].
References	[1]. Nicholas Denomme, et al. The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6. Neurosci Lett. 2020 Apr 17;724:134853.

Density	3.07g/cm3
Boiling Point	725.6ºC at 760mmHg
Molecular Formula	C₁₁H₁₄N₂O₂
Molecular Weight	206.24100
Flash Point	392.6ºC
Exact Mass	206.10600
PSA	56.06000
LogP	0.87730
Vapour Pressure	2.63E-24mmHg at 25°C
Index of Refraction	2.298

Precursor 2
CAS#:5141-89-9 (5S)-6,8t,10c-t... CAS#:13285-84-2 [(2S,3R,4S,11S,...
DownStream 0

Anhydro-epitetrodotoxin

anhydrotetrodotoxin

4,9-Anhydrotetrodotoxin

Use of 4,9-Anhydrotetrodotoxin

Names

4,9-Anhydrotetrodotoxin Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Synonyms