GNF179 (Metabolite)
Modify Date: 2024-01-09 16:37:11
GNF179 (Metabolite) structure
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Common Name | GNF179 (Metabolite) | ||
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| CAS Number | 1310455-86-7 | Molecular Weight | 245.29500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H16FN3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNF179 (Metabolite)GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.IC50 value: Target: Anti-parasitic agentGNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. |
| Name | 2-(4-fluorophenyl)-8,8-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine |
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| Synonym | More Synonyms |
| Description | GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.IC50 value: Target: Anti-parasitic agentGNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not. |
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| Related Catalog | |
| References |
| Molecular Formula | C14H16FN3 |
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| Molecular Weight | 245.29500 |
| Exact Mass | 245.13300 |
| PSA | 29.85000 |
| LogP | 2.85630 |
| Storage condition | 2-8℃ |
| GNF179 METABOLITE |
| GNF179 (Metabolite) |