AMZ30
Modify Date: 2024-01-22 17:34:13
AMZ30 structure
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Common Name | AMZ30 | ||
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| CAS Number | 1313613-09-0 | Molecular Weight | 461.444 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 724.3±70.0 °C at 760 mmHg | |
| Molecular Formula | C19H12FN3O6S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 391.9±35.7 °C | |
Use of AMZ30AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1(PME-1; IC50=600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.IC50 value: 600 nM [1]Target: PME-1 inhibitorin vitro: AMZ30 showed substantially improved inhibition of PME-1 (IC50 value of 600 nM) with more than 100-fold selectivity relative to other SHs in human cell lysates. Incubation of HEK 293T cells with a concentration range of AMZ30 generated an in situ IC50 value for PME-1 inhibition of 3.5 μM as determined by gel-based ABPP without any observed cross-reactivity with other SHs even at 100 μM compound. Treatment of HEK 293T cells stably overexpressing PME-1 with 28 (20 μM) caused an ~80% reduction in the levels of demethylated PP2A [1]. |
| Name | AMZ30 |
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| Synonym | More Synonyms |
| Description | AMZ30 is a selective, covalent inhibitors of protein phosphatase methylesterase-1(PME-1; IC50=600 nM); selectively inactivates PME-1 and reduces the demethylated form of PP2A in living cells.IC50 value: 600 nM [1]Target: PME-1 inhibitorin vitro: AMZ30 showed substantially improved inhibition of PME-1 (IC50 value of 600 nM) with more than 100-fold selectivity relative to other SHs in human cell lysates. Incubation of HEK 293T cells with a concentration range of AMZ30 generated an in situ IC50 value for PME-1 inhibition of 3.5 μM as determined by gel-based ABPP without any observed cross-reactivity with other SHs even at 100 μM compound. Treatment of HEK 293T cells stably overexpressing PME-1 with 28 (20 μM) caused an ~80% reduction in the levels of demethylated PP2A [1]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 724.3±70.0 °C at 760 mmHg |
| Molecular Formula | C19H12FN3O6S2 |
| Molecular Weight | 461.444 |
| Flash Point | 391.9±35.7 °C |
| Exact Mass | 461.015167 |
| LogP | 3.58 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.655 |
| Storage condition | 2-8℃ |
| (2E)-2-[(4-Fluorophenyl)sulfonyl]-3-{1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl}acrylonitrile |
| 2-Propenenitrile, 2-[(4-fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl]-, (2E)- |