RU-505

Modify Date: 2024-01-09 21:28:38

RU-505 Structure
RU-505 structure
Common Name RU-505
CAS Number 1314206-29-5 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula C28H32FN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RU-505


RU-505 is an effective β-amyloid (Aβ)-fibrinogen interaction inhibitor with IC50s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA). RU-505 can be used for the research of Alzheimer’s disease (AD)[1].

 Names

Name N-Benzyl-N-[2-(dimethylamino)ethyl]-7-(4-fluorophenyl)-2-(2-methyl-2-propanyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide
Synonym More Synonyms

 RU-505 Biological Activity

Description RU-505 is an effective β-amyloid (Aβ)-fibrinogen interaction inhibitor with IC50s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA). RU-505 can be used for the research of Alzheimer’s disease (AD)[1].
Related Catalog
References

[1]. Hyung Jin Ahn, et al. A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer's disease mice. J Exp Med. 2014 Jun 2;211(6):1049-62.

 Chemical & Physical Properties

Molecular Formula C28H32FN5O

 Synonyms

N-Benzyl-N-[2-(dimethylamino)ethyl]-7-(4-fluorophenyl)-2-(2-methyl-2-propanyl)pyrazolo[1,5-a]pyrimidine-5-carboxamide
MFCD06620515
Pyrazolo[1,5-a]pyrimidine-5-carboxamide, N-[2-(dimethylamino)ethyl]-2-(1,1-dimethylethyl)-7-(4-fluorophenyl)-N-(phenylmethyl)-
RU-505
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