AZD8529 mesylate
Modify Date: 2024-01-13 18:59:02
AZD8529 mesylate structure
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Common Name | AZD8529 mesylate | ||
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| CAS Number | 1314217-69-0 | Molecular Weight | 583.580 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H28F3N5O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZD8529 mesylateAZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes; potentiates agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus and striatum; decreases nicotine self-administration at doses (0.3-3 mg/kg) in monkeys, also reduces nicotine priming- and cue-induced reinstatement of nicotine seeking, decreases nicotine-induced accumbens dopamine release in rats. Schizophrenia Phase 2 Discontinued |
| Name | Azd-8529 Mesylate |
|---|---|
| Synonym | More Synonyms |
| Description | AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes; potentiates agonist-induced activation of mGluR2 in the membrane-binding assay and in primate cortex, hippocampus and striatum; decreases nicotine self-administration at doses (0.3-3 mg/kg) in monkeys, also reduces nicotine priming- and cue-induced reinstatement of nicotine seeking, decreases nicotine-induced accumbens dopamine release in rats. Schizophrenia Phase 2 Discontinued |
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| References | References 1. Justinova Z, et al. Biol Psychiatry. 2015 Oct 1;78(7):452-62. 2. Caprioli D, et al. Biol Psychiatry. 2015 Oct 1;78(7):463-73. 3. Li X, et al. Psychopharmacology (Berl). 2016 May;233(10):1801-14. 4. Augier E, et al. Neuropsychopharmacology. 2016 Nov;41(12):2932-2940. View Related Products by Target mGluR Schizophrenia |
| Molecular Formula | C25H28F3N5O6S |
|---|---|
| Molecular Weight | 583.580 |
| Exact Mass | 583.171265 |
| 1H-Isoindol-1-one, 2,3-dihydro-7-methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-, methanesulfonate (1:1) |
| 7-Methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]-1-isoindolinone methanesulfonate (1:1) |
| Azd-8529 Mesylate |