Odapipam

Modify Date: 2024-01-10 20:21:41

Odapipam structure	Common Name	Odapipam
	CAS Number	131796-63-9	Molecular Weight	329.82100
	Density	1.269g/cm3	Boiling Point	460.4ºC at 760mmHg
	Molecular Formula	C₁₉H₂₀ClNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	232.2ºC

Use of Odapipam

Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D1 receptor antagonist with a Kd of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer[1][2].

Name	(5S)-8-chloro-5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
Synonym	More Synonyms

Description	Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D1 receptor antagonist with a Kd of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Dopamine D1 receptor[1]
In Vivo	The metabolism of Odapipam has been studied with phenobarbital-induced rat liver microsomes. During the incubation of Odapipam, five different metabolites are formed. The electron-ionization (EI+) mass spectra of the metabolites indicated the formation of N-desmethyl-Odapipam, 1-hydroxy-Odapipam, the two isomers of 3′-hydroxy-Odapipam and a metabolite which is dehydrogenated in the dihydrobenzofuran moiety[3].
References	[1]. Abi-Dargham A, et al. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 1999 May;32(2):93-109. [2]. Nielsen EB, et al. Dopamine receptor occupancy in vivo: behavioral correlates using NNC-112, NNC-687 and NNC-756, new selective dopamine D1 receptor antagonists. Eur J Pharmacol. 1992 Aug 14;219(1):35-44. [3]. J. VANGGAARD ANDERSEN, et al. Normal-phase liquid chromatography-particle-beam mass spectrometry in drug metabolism studies of the dopamine receptor antagonist Odapipam and the muscarine M1 receptor agonist Xanomeline. Xenobiotica. 1997, 27: 901-912.

Density	1.269g/cm3
Boiling Point	460.4ºC at 760mmHg
Molecular Formula	C₁₉H₂₀ClNO₂
Molecular Weight	329.82100
Flash Point	232.2ºC
Exact Mass	329.11800
PSA	32.70000
LogP	3.53820
Vapour Pressure	4.27E-09mmHg at 25°C
Index of Refraction	1.623

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Odapipam

Nnc 756

UNII-847PQF7ZN6

Odapipam

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