5alpha-Hydroxycostic acid

Modify Date: 2024-01-01 17:59:36

5alpha-Hydroxycostic acid Structure
5alpha-Hydroxycostic acid structure
 Common Name 5alpha-Hydroxycostic acid
CAS Number 132185-83-2 Molecular Weight 250.333
Density 1.1±0.1 g/cm3 Boiling Point 406.4±38.0 °C at 760 mmHg
Molecular Formula C15H22O3 Melting Point N/A
MSDS N/A Flash Point 213.8±23.3 °C

 Use of 5alpha-Hydroxycostic acid


5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1].

 Names

Name 2-[(2R,4aR,8aR)-8a-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
Synonym More Synonyms

 5alpha-Hydroxycostic acid Biological Activity

Description 5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1].
Related Catalog
References

[1]. Liang N, et, al. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017 Jul;51(1):213-222.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 406.4±38.0 °C at 760 mmHg
Molecular Formula C15H22O3
Molecular Weight 250.333
Flash Point 213.8±23.3 °C
Exact Mass 250.156891
PSA 57.53000
LogP 3.19
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.540

 Safety Information

Hazard Codes Xi

 Synonyms

2-[(2R,4aR,8aR)-8a-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
2-Naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-α,8-bis(methylene)-, (2R,4aR,8aR)-
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