Tryptanthrine
Tryptanthrine structure
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Common Name | Tryptanthrine | ||
|---|---|---|---|---|
| CAS Number | 13220-57-0 | Molecular Weight | 248.23600 | |
| Density | 1.45g/cm3 | Boiling Point | 469.3ºC at 760 mmHg | |
| Molecular Formula | C15H8N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 237.7ºC | |
Use of TryptanthrineTryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits LT formation in human whole blood (IC50 = 10 µM) and reduces LTB4 levels in the rat pleurisy model[1]. |
| Name | Couroupitine A Indolo(2,1-b)quinazoline-6,12-dione Tryptanthrine |
|---|---|
| Synonym | More Synonyms |
| Description | Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin inhibits LT formation in human whole blood (IC50 = 10 µM) and reduces LTB4 levels in the rat pleurisy model[1]. |
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| Related Catalog | |
| Target |
IC50: 10 µM (LT formation in human whole blood)[1] |
| References |
| Density | 1.45g/cm3 |
|---|---|
| Boiling Point | 469.3ºC at 760 mmHg |
| Molecular Formula | C15H8N2O2 |
| Molecular Weight | 248.23600 |
| Flash Point | 237.7ºC |
| Exact Mass | 248.05900 |
| PSA | 51.96000 |
| LogP | 1.93010 |
| Vapour Pressure | 5.55E-09mmHg at 25°C |
| Index of Refraction | 1.762 |
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Tryptanthrin ameliorates atopic dermatitis through down-regulation of TSLP.
Arch. Biochem. Biophys. 542 , 14-20, (2014) Atopic dermatitis (AD) is a common skin disease that greatly worsens quality of life. Thymic stromal lymphopoietin (TSLP) plays a decisive role in the development of AD. The purpose of this study is t... |
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Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells.
J. Ethnopharmacol. 174 , 474-81, (2015) Indigo naturalis has been used to treat inflammatory diseases and dermatosis, including psoriasis, since thousands of years in China. It has been proven effective in our previous clinical studies on t... |
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Kourokhitin, a potential drug containing two active substances.
Dokl. Biochem. Biophys. 426 , 131-3, (2009)
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| Tryptanthrin |
| MFCD00012073 |
| indolo[2,1-b]quinazoline-6,12-dione |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Tryptanthrine
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Tryptanthrine
- Price: ￥2658.0/5g ￥828.0/1g
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Indolo[2,1-b]quinazoline-6,12-dione
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
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- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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