Memantine-d3 hydrochloride

Modify Date: 2024-01-16 19:42:04

Memantine-d3 hydrochloride Structure
Memantine-d3 hydrochloride structure
Common Name Memantine-d3 hydrochloride
CAS Number 1329802-06-3 Molecular Weight 218.78
Density N/A Boiling Point N/A
Molecular Formula C12H19D3ClN Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Memantine-d3 hydrochloride


Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].

 Names

Name 3-Methyl-5-(2H3)methyl-1-adamantanamine hydrochloride (1:1)
Synonym More Synonyms

 Memantine-d3 hydrochloride Biological Activity

Description Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25(17):4005. Published 2020 Sep 2.

[3]. Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19.

[4]. Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273.

 Chemical & Physical Properties

Molecular Formula C12H19D3ClN
Molecular Weight 218.78
Exact Mass 218.162903

 Synonyms

Tricyclo[3.3.1.13,7]decan-1-amine, 3-methyl-5-(methyl-d3)-, hydrochloride (1:1)
3-Methyl-5-(2H3)methyl-1-adamantanamine hydrochloride (1:1)