Ropeginterferon alfa-2b
Modify Date: 2024-04-06 08:38:53
Ropeginterferon alfa-2b structure
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Common Name | Ropeginterferon alfa-2b | ||
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| CAS Number | 1335098-50-4 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ropeginterferon alfa-2bRopeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms[1]. |
| Name | Ropeginterferon alfa-2b |
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| Description | Ropeginterferon alfa-2b (Ropeginterferon alfa-2b-njft) is a monopegylated IFN-α that can be used for the research of myeloproliferative neoplasms[1]. |
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| Related Catalog | |
| In Vitro | Ropeginterferon alfa-2b (5 μg/mL; 72 h) suppresses growth, induces apoptosis and arrests cell cycle at G1 phase in BA-1 cells[1]. Cell Proliferation Assay[1] Cell Line: BA-1 cells Concentration: 5 μg/mL Incubation Time: 72 h Result: Suppressed BA-1 growth. Apoptosis Analysis[1] Cell Line: BA-1 cells Concentration: 5 μg/mL Incubation Time: 24, 48 and 72 h Result: Showed an increase in early- and late-apoptotic cells in a time-dependent manner. Promoted a time-dependent increase in caspase-3 expression. Cell Cycle Analysis[1] Cell Line: BA-1 cells Concentration: 5 μg/mL Incubation Time: 24, 48 and 72 h Result: Induced an increase in G1 phase. |
| In Vivo | Ropeginterferon alfa-2b (5 μg/mouse; s.c.; single dose) 降低白血病负担，延长白血病小鼠存活时间[1]。 Animal Model: C57BL/6 mice (8-12 weeks) with BA-1 cells[1] Dosage: 5 μg/mouse Administration: Subcutaneous injection, on day 5 after tumor inoculation Result: Led to long-term remission in four of eight (50%) mice. |
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| No Any Chemical & Physical Properties |