Dolutegravir intermediate-1

Modify Date: 2024-01-03 02:15:20

Dolutegravir intermediate-1 Structure
Dolutegravir intermediate-1 structure
Common Name Dolutegravir intermediate-1
CAS Number 1335210-23-5 Molecular Weight 315.276
Density 1.4±0.1 g/cm3 Boiling Point 474.1±45.0 °C at 760 mmHg
Molecular Formula C13H17NO8 Melting Point N/A
MSDS N/A Flash Point 240.5±28.7 °C

 Use of Dolutegravir intermediate-1


Dolutegravir intermediate-1 is a novel synthetic intermediate of dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-l infection.

 Names

Name 2,​5-​Pyridinedicarboxylic acid, 1-​(2,​2-​dimethoxyethyl)​-​1,​4-​dihydro-​3-​methoxy-​4-​oxo-​, 2-​methyl ester
Synonym More Synonyms

 Dolutegravir intermediate-1 Biological Activity

Description Dolutegravir intermediate-1 is a novel synthetic intermediate of dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-l infection.
Related Catalog
References

[1]. Sivaram Prasad, et al. Process for the preparation of dolutegravir . WO 2016125192 A2.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 474.1±45.0 °C at 760 mmHg
Molecular Formula C13H17NO8
Molecular Weight 315.276
Flash Point 240.5±28.7 °C
Exact Mass 315.095428
PSA 113.29000
LogP -1.00
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.536
Storage condition 2-8℃

 Synonyms

1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid
2,5-Pyridinedicarboxylic acid, 1-(2,2-dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-, 2-methyl ester
1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
Dolutegravir intermediate-1
1-(2,2-Dimethoxyethyl)-1,4-dihydro-3-methoxy-4-oxo-2,5-pyridinedicarboxylic acid 2-methyl ester
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Price: $83/10mM*1mLinDMSO

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