Nevanimibe hydrochloride
Modify Date: 2024-01-02 11:01:38
Nevanimibe hydrochloride structure
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Common Name | Nevanimibe hydrochloride | ||
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| CAS Number | 133825-81-7 | Molecular Weight | 458.07900 | |
| Density | N/A | Boiling Point | 528.1ºC at 760 mmHg | |
| Molecular Formula | C27H40ClN3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 273.2ºC | |
Use of Nevanimibe hydrochlorideNevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) is a selective and potent acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) inhibits ACAT2 with an EC50 of 368 nM[1]. |
| Name | 1-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]-3-[2,6-di(propan-2-yl)phenyl]urea,hydrochloride |
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| Synonym | More Synonyms |
| Description | Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) is a selective and potent acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride (PD-132301 hydrochloride; ATR101 hydrochloride) inhibits ACAT2 with an EC50 of 368 nM[1]. |
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| Related Catalog | |
| Target |
ACAT1:9 nM (EC50) ACAT2:368 nM (EC50) |
| In Vitro | Coincubation of Nevanimibe (ATR-101; 3 nM-30 μM) and Cholesterol markedly increases toxicity in a dose-dependent manner, where 3 nM Nevanimibe in the presence of 60 μg/mL Cholesterol reduces survival by 60% after 24 hours. All doses of Nevanimibe (3 nM-30 μM) induces cytoxicity in the presence of Cholesterol, whereas treatment with Cholesterol in the absence of Nevanimibe has no effect on cell viability[1]. Cell Cytotoxicity Assay[1] Cell Line: The H295R and HAC clone 15 (HAC15) human ACC cell lines Concentration: 3 nM-30 μM Incubation Time: 24 hours Result: 3 nM-3 μM exhibited no toxicity, whereas 30 μM treatment reduced survival by approximately 40% within 24 hours. |
| References |
| Boiling Point | 528.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C27H40ClN3O |
| Molecular Weight | 458.07900 |
| Flash Point | 273.2ºC |
| Exact Mass | 457.28600 |
| PSA | 47.86000 |
| LogP | 7.71230 |
| Vapour Pressure | 3.05E-11mmHg at 25°C |
| Storage condition | 2-8℃ |
| Urea,N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)-,monohydrochloride |
| C27H39N3O.HCl |
| N-(2,6-Bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl)methyl)urea HCl |