2-Iminobiotin
2-Iminobiotin structure
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Common Name | 2-Iminobiotin | ||
|---|---|---|---|---|
| CAS Number | 13395-35-2 | Molecular Weight | 243.326 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 477.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C10H17N3O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 242.5±31.5 °C | |
Use of 2-Iminobiotin2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2]. |
| Name | 5-[(3aS,4S,6aR)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | 2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5μM for murine iNOS and rat n-cNOS, respectively[1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage[2]. |
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| Related Catalog | |
| Target |
Nitric oxide synthases[1] |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 477.3±55.0 °C at 760 mmHg |
| Molecular Formula | C10H17N3O2S |
| Molecular Weight | 243.326 |
| Flash Point | 242.5±31.5 °C |
| Exact Mass | 243.104141 |
| PSA | 110.51000 |
| LogP | -0.36 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.737 |
| Storage condition | 2~8°C |
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2-Iminobiotin CAS#:13395-35-2 |
| Literature: Journal of Biological Chemistry, , vol. 187, p. 29,31 |
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Influence of different classes of NO synthase inhibitors in the pig gastric fundus.
Naunyn Schmiedebergs Arch. Pharmacol. 356(4) , 488-94, (1997) The inhibitory potency of different classes of nitric oxide synthase (NOS) inhibitors (amino acid-based substances, guanidines, isothioureas, imidazoles and indazoles) versus peripheral neuronal NOS i... |
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Intermolecular forces and energies between ligands and receptors.
Science 266(5183) , 257-9, (1994) The recognition mechanisms and dissociation pathways of the avidin-biotin complex and of actin monomers in actin filaments were investigated. The unbinding forces of discrete complexes of avidin or st... |
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Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia.
Dev. Neurosci. 24(5) , 396-404, (2002) Selective inhibition of neuronal and inducible nitric oxide synthase (NOS) with 2-iminobiotin previously showed a reduction in brain cell injury. In the present study, we investigated the effects of 2... |
| 2izl |
| Guanidinobiotin Hexahydro-2-imino-1H-thieno[3,4-d]imidazole-4-pentanoic acid |
| 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, 2-amino-3a,4,6,6a-tetrahydro-, (3aS,4S,6aR)- |
| MFCD00149243 |
| 2-Iminobiotin |
| EINECS 236-308-9 |
| Guanidinobiotin |
| 5-[(3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]pentanoic acid |
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
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