Aconiazide

Modify Date: 2024-01-07 02:40:06

Aconiazide Structure
Aconiazide structure
Common Name Aconiazide
CAS Number 13410-86-1 Molecular Weight 299.28100
Density 1.3g/cm3 Boiling Point N/A
Molecular Formula C15H13N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Aconiazide


Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis[1].

 Names

Name 2-[2-[(E)-(pyridine-4-carbonylhydrazinylidene)methyl]phenoxy]acetic acid
Synonym More Synonyms

 Aconiazide Biological Activity

Description Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis[1].
Related Catalog
References

[1]. KENNETH L. DOOLEY, et al. Fourteen-Day , Repeat-Dose Toxicity Evaluation of Aconiazide _- Administered Orally to Male and Female Fischer 344 Rats. JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY Vdume 12, Number 4, 1993

 Chemical & Physical Properties

Density 1.3g/cm3
Molecular Formula C15H13N3O4
Molecular Weight 299.28100
Exact Mass 299.09100
PSA 100.88000
LogP 1.69980
Index of Refraction 1.61

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US5638000
CHEMICAL NAME :
4-Pyridinecarboxylic acid, ((2-(carboxymethoxy)phenyl)methylene)hydrazide
CAS REGISTRY NUMBER :
13410-86-1
BEILSTEIN REFERENCE NO. :
0300804
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H13-N3-O4
MOLECULAR WEIGHT :
299.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg/14D-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,329,1993
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
36400 mg/kg/26W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - structural change in nerve or sheath Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,328,1995

 Safety Information

HS Code 2933399090

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

[2-(isonicotinoylhydrazono-methyl)-phenoxy]-acetic acid
Isonicophen
Aconiazid
Phenoxalid
ACONIAZIDE
[2-(Isonicotinoylhydrazono-methyl)-phenoxy]-essigsaeure