Atorvastatin Sodium

Modify Date: 2024-01-08 06:42:00

Atorvastatin Sodium structure	Common Name	Atorvastatin Sodium
	CAS Number	134523-01-6	Molecular Weight	580.62
	Density	1.2±0.1 g/cm3	Boiling Point	722.2±60.0ºC at 760 mmHg
	Molecular Formula	C₃₃H₃₄FN₂NaO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	390.6±32.9ºC

Use of Atorvastatin Sodium

Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5].

Name	atorvastatin sodium
Synonym	More Synonyms

Description	Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR) Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
References	[1]. Br J Pharmacol. 2006 Sep;149(1):14-22. [2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. [3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82. [4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72. [5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821. [6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

References

[1]. Br J Pharmacol. 2006 Sep;149(1):14-22.

[2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

[3]. Nawrocki, J.W., et al., Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol, 1995. 15(5): p. 678-82.

[4]. Song XJ, et al. Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response. Int J Med Sci. 2011;8(7):564-72.

[5]. Li Y, et al. Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm. PLoS One. 2017 Apr 3;12(4):e0174821.

[6]. Ming-Bai Hu, et al. Atorvastatin induces autophagy in MDA-MB-231 breast cancer cells. Ultrastruct Pathol. Sep-Oct 2018;42(5):409-415.

Density	1.2±0.1 g/cm3
Boiling Point	722.2±60.0ºC at 760 mmHg
Molecular Formula	C₃₃H₃₄FN₂NaO₅
Molecular Weight	580.62
Flash Point	390.6±32.9ºC
Exact Mass	580.234924
PSA	114.62000
LogP	5.05190

Precursor 9
CAS#:134395-00-9 Atorvastatin te... CAS#:134523-00-5 Atorvastatin CAS#:849928-46-7 tert-butyl 2-((... CAS#:125971-95-1 Atorvastatin Ac...
CAS#:697266-12-9 [R(R,R)]-2-(4... CAS#:125971-94-0 (4R,6R)-tert-Bu... CAS#:125995-03-1 Atorvastatin lactone CAS#:472967-95-6 tert-butyl 2-[(...
CAS#:1146977-93-6 Atorvastatin Et...
DownStream 1
CAS#:134523-00-5 Atorvastatin