Befloxatone
Modify Date: 2024-01-03 22:25:52
Befloxatone structure
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Common Name | Befloxatone | ||
|---|---|---|---|---|
| CAS Number | 134564-82-2 | Molecular Weight | 349.30200 | |
| Density | 1.326g/cm3 | Boiling Point | 447.3ºC at 760mmHg | |
| Molecular Formula | C15H18F3NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 224.3ºC | |
Use of BefloxatoneBefloxatone (MD-370503) is an orally active, selective and reversible inhibitor of Monoamine Oxidase A (MAO-A) (IC50=4 nM). Befloxatone increases the tissue level of monoamine, striatal dopamine and cortical norepinephrine. Befloxatone has antidepressant potential[1]. |
| Name | (5R)-5-(methoxymethyl)-3-[4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl]-1,3-oxazolidin-2-one |
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| Synonym | More Synonyms |
| Description | Befloxatone (MD-370503) is an orally active, selective and reversible inhibitor of Monoamine Oxidase A (MAO-A) (IC50=4 nM). Befloxatone increases the tissue level of monoamine, striatal dopamine and cortical norepinephrine. Befloxatone has antidepressant potential[1]. |
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| Related Catalog | |
| Target |
MAO-A:4 nM (IC50) MAO-B:300 nM (IC50) |
| In Vitro | Befloxatone (100 nM; 0-100 min) 可逆抑制大鼠脑匀浆中的 MAO-A 活性，60 min 后不再发挥抑制作用[1]。 |
| In Vivo | Befloxatone (0.75 mg/kg; i.p.; single dose) 在大鼠中增加单胺的组织水平，并降低其脱氨基代谢物的水平[1]。 Befloxatone (1 mg/kg; i.p.; single dose) 可诱导大鼠细胞外纹状体多巴胺和皮质去甲肾上腺素水平升高，但不诱导皮质 5-羟色胺水平升高[1]。 Befloxatone (0.03-0.3 mg/kg; p.o.; single dose) 在大鼠中有效抑制血清素能神经元的放电速率，部分降低去甲肾上腺素能神经元的发射，对多巴胺能神经元的激发没有影响[1]。 Befloxatone (1.5 mg/kg; p.o.; single dose) 在大鼠中不会增强中心活性剂量口服酪胺的升压作用，具有广泛的安全性[1]。 |
| References |
| Density | 1.326g/cm3 |
|---|---|
| Boiling Point | 447.3ºC at 760mmHg |
| Molecular Formula | C15H18F3NO5 |
| Molecular Weight | 349.30200 |
| Flash Point | 224.3ºC |
| Exact Mass | 349.11400 |
| PSA | 68.23000 |
| LogP | 2.41530 |
| Vapour Pressure | 8.73E-09mmHg at 25°C |
| Index of Refraction | 1.498 |
| UNII-4H75PAD8M3 |
| (R)-5-(methoxymethyl)-3-(p[(R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl)-2-oxazolidinone |
| BEFLOXATONE |
| (R)-5-(methoxymethyl)-3-(4-((R)-4,4,4-trifluoro-3-hydroxybutoxy)phenyl)-oxazolidin-2-one |
| Befloxatone (INN) |