Lamivudine

Modify Date: 2024-01-02 14:15:06

Lamivudine Structure
Lamivudine structure
Common Name Lamivudine
CAS Number 134678-17-4 Molecular Weight 229.256
Density 1.7±0.1 g/cm3 Boiling Point 475.4±55.0 °C at 760 mmHg
Molecular Formula C8H11N3O3S Melting Point 177 °C
MSDS Chinese USA Flash Point 241.3±31.5 °C
Symbol GHS08
GHS08
Signal Word Warning

 Use of Lamivudine


Lamivudine is a nucleoside reverse transcriptase inhibitors?(NRTIs). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus.

 Names

Name lamivudine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 475.4±55.0 °C at 760 mmHg
Melting Point 177 °C
Molecular Formula C8H11N3O3S
Molecular Weight 229.256
Flash Point 241.3±31.5 °C
Exact Mass 229.052109
PSA 115.67000
LogP -0.71
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.755
Storage condition Freezer

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361
Precautionary Statements P281
Hazard Codes Xi
Risk Phrases 63
RIDADR NONH for all modes of transport
RTECS UW7361333
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2938901000
Summary HS: 2938901000. 4-amino-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1h)-one. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:None. MFN tarrif:6.5%. general tariff:20.0%

 Articles117

More Articles
Transporter-mediated uptake of UDP-glucuronic acid by human liver microsomes: assay conditions, kinetics, and inhibition.

Drug Metab. Dispos. 43(1) , 147-53, (2014)

This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.

Anal. Bioanal. Chem 407(8) , 2073-84, (2015)

A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtrici...

The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium.

Environ. Mol. Mutagen. 54(4) , 268-80, (2013)

The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses...

 Synonyms

2(1H)-Pyrimidinone, 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
3TC
Heptodin
cent
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
Lamivudine
Zeffix
Zefix
Hepitec
Heptivir
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2',3'-Dideoxy-3'-thiacytidine
Heptovir
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
MFCD00869739
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cystosine
4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Epivir
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
3&L-SddC
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