8-M-PDOT
Modify Date: 2024-01-13 11:33:04
8-M-PDOT structure
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Common Name | 8-M-PDOT | ||
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| CAS Number | 134865-70-6 | Molecular Weight | 233.30600 | |
| Density | 1.09g/cm3 | Boiling Point | 447.8ºC at 760 mmHg | |
| Molecular Formula | C14H19NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 224.6ºC | |
Use of 8-M-PDOT8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2]. |
| Name | N-[(2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]propanamide |
|---|---|
| Synonym | More Synonyms |
| Description | 8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2]. |
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| Related Catalog | |
| Target |
pKi: 8.23 (Melatonin MT2 receptor) and 8.95 (Melatonin MT1 receptor)[2] |
| In Vivo | 8-M-PDOT (10 µg/µL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2]. Animal Model: Male Wistar rats (280-320 g) with Rotenone[2] Dosage: 10 µg/µL Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes Result: Increased percentage of time spent in the open arms and in the number of open arms entries. |
| References |
| Density | 1.09g/cm3 |
|---|---|
| Boiling Point | 447.8ºC at 760 mmHg |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.30600 |
| Flash Point | 224.6ºC |
| Exact Mass | 233.14200 |
| PSA | 38.33000 |
| LogP | 2.46960 |
| Vapour Pressure | 3.27E-08mmHg at 25°C |
| Index of Refraction | 1.542 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
CAS#:123-62-6
CAS#:3880-76-0| 8-methoxy-2-propionamidotetralin |
| Tocris-1035 |
| 8-M-PDOT |