Lefamulin acetate
Modify Date: 2024-01-09 19:37:38
Lefamulin acetate structure
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Common Name | Lefamulin acetate | ||
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| CAS Number | 1350636-82-6 | Molecular Weight | 567.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H49NO7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lefamulin acetateLefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate (BC-3781 acetate) is the first semi-synthetic pleuromutilin for systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer[1]. |
| Name | Lefamulin acetate |
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| Synonym | More Synonyms |
| Description | Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate (BC-3781 acetate) is the first semi-synthetic pleuromutilin for systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer[1]. |
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| Related Catalog | |
| In Vitro | Lefamulin acetate (BC-3781 acetate) has activity against the resistant gram-postive organisms, including taphylococcus aureus (MRSA) (MIC50=0.12 μg/ml; MIC90=0.25 μg/ml); β-Hemolytic strepococcus (MIC50=0.03 μg/ml; MIC90=0.03 μg/ml); Viridans group Streptococcus (MIC50=0.12 μg/ml; MIC90=0.5 μg/ml), Enterocossus faecium (MIC50=0.12 μg/ml; MIC90=4 μg/ml), Streptococcus pneumonia (MIC50=0.12 μg/ml; MIC90=0.25 μg/ml)[1]. Lefamulin has activity against gram-negative organisms, including Haemophilus influenza (MIC50=1 μg/ml; MIC90=0.12 μg/ml) and Moraxella cotarrhali (MIC50=2 μg/ml; MIC90=0.25 μg/ml)[1]. |
| References |
| Molecular Formula | C30H49NO7S |
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| Molecular Weight | 567.78 |
| Storage condition | 2-8°C |
| MFCD28963990 |