Strontium Ranelate

Modify Date: 2024-01-02 16:29:50

Strontium Ranelate Structure
Strontium Ranelate structure
 Common Name Strontium Ranelate
CAS Number 135459-87-9 Molecular Weight 513.49
Density 1.8±0.1 g/cm3 Boiling Point 778.8±60.0 °C at 760 mmHg
Molecular Formula C12H6N2O8SSr2 Melting Point >310°C (dec.)
MSDS Chinese USA Flash Point 424.8±32.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Strontium Ranelate


Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis.

 Names

Name 2,2'-((5-Carboxy-4-(carboxymethyl)-3-cyanothiophen-2-yl)azanediyl)diacetic acid, distrontium salt
Synonym More Synonyms

 Strontium Ranelate Biological Activity

Description Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis.
Related Catalog
References

[1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12.

[2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.

[3]. P. J. Marie .Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporosis International. 2005,16(1): S7-S10

[4]. Sorbera, L.A., Castaner, et al . Strontium Ranelate .Drugs Fut 2003, 28(4): 328

[5]. J Buehler, P Chappuis, J.L Saffar, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001,29(2): 176-179.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 778.8±60.0 °C at 760 mmHg
Melting Point >310°C (dec.)
Molecular Formula C12H6N2O8SSr2
Molecular Weight 513.49
Flash Point 424.8±32.9 °C
PSA 160.47000
LogP -0.90
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.695
Storage condition -20°C Freezer
Water Solubility H2O: soluble1mg/mL, clear (warmed)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302 + H312 + H332
Precautionary Statements P280
Hazard Codes Xn
Risk Phrases 20/21/22
Safety Phrases 36/37
RIDADR 3077
RTECS XM7581000
HS Code 2942000000

 Customs

HS Code 2942000000

 Synonyms

3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-
5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid
5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid
Strontium Ranelate
Ranelic Acid Strontium Salt
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