Perindopril-d4 erbumine

Modify Date: 2024-01-14 21:56:09

Perindopril-d4 erbumine Structure
Perindopril-d4 erbumine structure
Common Name Perindopril-d4 erbumine
CAS Number 1356929-59-3 Molecular Weight 445.62900
Density N/A Boiling Point N/A
Molecular Formula C23H39D4N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Perindopril-d4 erbumine


Perindopril-d4 t-butylamine salt is the deuterium labeled Perindopril t-butylamine salt. Perindopril t-butylamine salt is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease[1][2].

 Names

Name Perindopril-d4 t-Butylamine Salt
Synonym More Synonyms

 Perindopril-d4 erbumine Biological Activity

Description Perindopril-d4 t-butylamine salt is the deuterium labeled Perindopril t-butylamine salt. Perindopril t-butylamine salt is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Vaclavik J, Perindopril in the treatment of hypertension and cardiovascular diseases: evolution continues with the orodispersible dosage form. Vnitr Lek. 2013 Apr;59(4):290-4.

[3]. Napalkov DA. Therapy with perindopril: organoprotection, not just the antihypertensive effect. Kardiologiia. 2012;52(12):80-3.

 Chemical & Physical Properties

Molecular Formula C23H39D4N3O5
Molecular Weight 445.62900
Exact Mass 445.34500
PSA 121.96000
LogP 3.71330

 Synonyms

(2S,3aS,7aS)-1-[2,3,3,3-tetradeuterio-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid,2-methylpropan-2-amine