6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide
Modify Date: 2024-05-23 21:00:23
![6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide Structure](https://www.chemsrc.com/caspic/079/1357158-81-6.png)
6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide structure
|
Common Name | 6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide | ||
|---|---|---|---|---|
| CAS Number | 1357158-81-6 | Molecular Weight | 343.422 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 496.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C22H21N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 254.0±28.7 °C | |
Use of 6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamideAKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. |
| Name | 6-(4-(1-aminocyclobutyl)phenyl)-5-phenylnicotinamide |
|---|---|
| Synonym | More Synonyms |
| Description | AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.042 μM (AKT)[1] |
| In Vitro | AKT-IN-1 (Compound 26) is able to potently inhibit phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM, respectively. AKT-IN-1 inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway. AKT-IN-1 potently inhibits the phosphorylation of PRAS40[1]. |
| In Vivo | The effects of AKT-IN-1 (Compound 26) in vivo are characterized by measuring the pharmacodynamic activity of AKT-IN-1 in a BT474c breast adenocarcinoma xenograft model. Following acute doses of 100 and 200 mg/kg, AKT-IN-1 potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473), with a potency consistent with its pharmacokinetic profile. The in vivo activity of AKT-IN-1 is further characterized by measuring the effects on the growth of tumor cell xenografts. Continuous (daily) oral dosing of AKT-IN-1 (100 and 200 mg/kg) to nude mice bearing BT474c breast adenocarcinoma xenografts results in inhibition of tumor growth in a dose-dependent manner. When dosed at 200 mg/kg daily, AKT-IN-1 causes significant tumor growth inhibition[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 496.4±45.0 °C at 760 mmHg |
| Molecular Formula | C22H21N3O |
| Molecular Weight | 343.422 |
| Flash Point | 254.0±28.7 °C |
| Exact Mass | 343.168457 |
| PSA | 82.00000 |
| LogP | 2.87 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.643 |
| Storage condition | 2-8℃ |
| Water Solubility | Practically insoluble (0.041 g/L) (25 ºC) |
| 6-[4-(1-Aminocyclobutyl)phenyl]-5-phenylnicotinamide |
| 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-phenyl- |
| 6-[4-(1-Aminocyclobutyl)phenyl]-5-phenyl-3-pyridinecarboxamide |
| AZD-26 |
| AKT-IN-1 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: AKT-IN-1
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: AZD-26(AKT-IN-1）
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: AZD-26(AKT-IN-1）
- Price: $750.0/100mg $1500.0/250mg $3000.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥3630/10 mM * 1 mL in DMSO
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