ML 228
Modify Date: 2024-01-20 12:09:33
ML 228 structure
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Common Name | ML 228 | ||
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| CAS Number | 1357171-62-0 | Molecular Weight | 415.489 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 686.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C27H21N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 368.7±34.3 °C | |
Use of ML 228ML228(CID-46742353) is an activator of the Hypoxia Inducible Factor (HIF) pathway; potently activate HIF in vitro as well as its downstream target VEGF.IC50 value: 1 uM (EC50) [1]Target: HIF activatorML228 represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications. |
| Name | N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine |
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| Synonym | More Synonyms |
| Description | ML228(CID-46742353) is an activator of the Hypoxia Inducible Factor (HIF) pathway; potently activate HIF in vitro as well as its downstream target VEGF.IC50 value: 1 uM (EC50) [1]Target: HIF activatorML228 represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 686.0±65.0 °C at 760 mmHg |
| Molecular Formula | C27H21N5 |
| Molecular Weight | 415.489 |
| Flash Point | 368.7±34.3 °C |
| Exact Mass | 415.179688 |
| PSA | 63.59000 |
| LogP | 5.05 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.671 |
| Storage condition | 2-8℃ |
| 1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)- |
| N-(4-Biphenylylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine |
| ML228 |