RP 67580

Modify Date: 2024-03-08 23:01:19

RP 67580 Structure
RP 67580 structure
Common Name RP 67580
CAS Number 135911-02-3 Molecular Weight 438.56
Density 1.17 g/cm3 Boiling Point 588.5ºC at 760 mmHg
Molecular Formula C29H30N2O2 Melting Point 195-188ºC
MSDS N/A Flash Point 309.7ºC

 Use of RP 67580


RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation[1].

 Names

Name (3aR,7aR)-2-[2-(2-methoxyphenyl)ethanimidoyl]-7,7-diphenyl-1,3,3a,5,6,7a-hexahydroisoindol-4-one
Synonym More Synonyms

 RP 67580 Biological Activity

Description RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation[1].
Related Catalog
In Vivo RP 67580(0.03-1 mg/kg;静脉注射;单剂量)显著抑制神经源性炎症。 Animal Model: Male albino Sprague-Dawley rats Dosage: 0.03, 0.1, 0.3, 1 mg/kg Administration: i.v.; single dose Result: Potently and dose-dependently inhibited the strong plasma extravasation caused by electrical stimulation of the saphenous nerve for 15 minutes with an ED50 value of 0.15 mg/kg.
References

[1]. Garret C, et al. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208-12.  

 Chemical & Physical Properties

Density 1.17 g/cm3
Boiling Point 588.5ºC at 760 mmHg
Melting Point 195-188ºC
Molecular Formula C29H30N2O2
Molecular Weight 438.56
Flash Point 309.7ºC
Exact Mass 438.23100
PSA 53.39000
LogP 5.14980
Vapour Pressure 7.89E-14mmHg at 25°C
Index of Refraction 1.626

 Synonyms

Tocris-1635
RP-67580
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