(3R,4R)-A2-32-01

Modify Date: 2024-01-02 14:44:36

(3R,4R)-A2-32-01 Structure
(3R,4R)-A2-32-01 structure
Common Name (3R,4R)-A2-32-01
CAS Number 1359752-95-6 Molecular Weight 301.42
Density N/A Boiling Point N/A
Molecular Formula C19H27NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (3R,4R)-A2-32-01


(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity[1].

 Names

Name (3R,4R)-A2-32-01

 (3R,4R)-A2-32-01 Biological Activity

Description (3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity[1].
Related Catalog
In Vitro (3R,4R)-A2-32-01 inhibits hemolysis with an ED50 of 15 nmol on blood agar plates[1]. (3R,4R)-A2-32-01 exhibits EC50s of 50 μM and 75 μM in dropping metabolic activity of NIH3T3 fibroblasts and HaCat keratinocytes, respectively[1].
References

[1]. Zeiler E, et al. Development and characterization of improved β-lactone-based anti-virulence drugs targetingClpP. Bioorg Med Chem. 2012 Jan 15;20(2):583-91.

 Chemical & Physical Properties

Molecular Formula C19H27NO2
Molecular Weight 301.42
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