PAT-048
Modify Date: 2024-01-10 10:23:48
PAT-048 structure
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Common Name | PAT-048 | ||
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| CAS Number | 1359983-15-5 | Molecular Weight | 461.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18ClF2N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAT-048PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo[1][2]. |
| Name | PAT-048 |
|---|
| Description | PAT-048 is a potent, selective and orally active autotaxin inhibitor, inhibits IL-6 mRNA expression, but shows no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in lung fibrosis model. PAT-048 shows an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. PAT-048 reduces dermal fibrosis in vivo[1][2]. |
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| Related Catalog | |
| Target |
IC50: 20 nM (Autotaxin, in mouse plasma)[1] IC90: 200 nM (Autotaxin, in mouse plasma)[1] |
| References |
| Molecular Formula | C22H18ClF2N3O2S |
|---|---|
| Molecular Weight | 461.91 |