BI 665915
Modify Date: 2024-03-03 18:43:29
BI 665915 structure
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Common Name | BI 665915 | ||
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| CAS Number | 1360550-04-4 | Molecular Weight | 458.516 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 738.8±70.0 °C at 760 mmHg | |
| Molecular Formula | C24H26N8O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 400.6±35.7 °C | |
Use of BI 665915BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM; displays no activity against other enzymes and receptors in the leukotriene pathway such as 5-LO, COX-1 and -2, phospholipase A2, LTA4 hydrolase, BLT1, and BLT2 (IC50s>10 uM); shows functional inhibition of LTB4 production in human whole blood (IC50=45 nM); demonstrates a dose-dependent DMPK relationship and inhibition of LTB4production in vivo. |
| Name | 2-[4-(3-{(1R)-1-[4-(2-Amino-5-pyrimidinyl)phenyl]-1-cyclopropylethyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]-N,N-dimethylacetamide |
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| Synonym | More Synonyms |
| Description | BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM; displays no activity against other enzymes and receptors in the leukotriene pathway such as 5-LO, COX-1 and -2, phospholipase A2, LTA4 hydrolase, BLT1, and BLT2 (IC50s>10 uM); shows functional inhibition of LTB4 production in human whole blood (IC50=45 nM); demonstrates a dose-dependent DMPK relationship and inhibition of LTB4production in vivo. |
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| References | References 1. Takahashi H, et al. J Med Chem. 2015 Feb 26;58(4):1669-90. View Related Products by Target FLAP |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 738.8±70.0 °C at 760 mmHg |
| Molecular Formula | C24H26N8O2 |
| Molecular Weight | 458.516 |
| Flash Point | 400.6±35.7 °C |
| Exact Mass | 458.217865 |
| LogP | 1.75 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.717 |
| MFCD28902241 |
| 1H-Pyrazole-1-acetamide, 4-[3-[(1R)-1-[4-(2-amino-5-pyrimidinyl)phenyl]-1-cyclopropylethyl]-1,2,4-oxadiazol-5-yl]-N,N-dimethyl- |
| 2-[4-(3-{(1R)-1-[4-(2-Amino-5-pyrimidinyl)phenyl]-1-cyclopropylethyl}-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl]-N,N-dimethylacetamide |