ML368

Modify Date: 2024-05-12 14:01:24

ML368 Structure
ML368 structure
Common Name ML368
CAS Number 1361414-26-7 Molecular Weight 430.46100
Density N/A Boiling Point N/A
Molecular Formula C26H18N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML368


SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism[1].

 Names

Name 1-(4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl)-3-(4'-cyano-[1,1'-biphenyl]-4-yl)urea
Synonym More Synonyms

 ML368 Biological Activity

Description SR9186 (ML368) is a potent CYP3A4 inhibitor with IC50 s for inhibition of midazolam → 1′hydroxymidazolam, testosterone → 6β-hydroxytestosterone, and vincristine → vincristine M1 of 9, 4, and 38 nM, respectively. SR-9186 inhibits liver-stage development of P. falciparum to block ivermectin metabolism[1].
Related Catalog
References

[1]. Xiaohai Li, et al. Discovery of a highly selective CYP3A4 inhibitor suitable for reaction phenotyping studies and differentiation of CYP3A4 and CYP3A5. Drug Metab Dispos. 2012 Sep;40(9):1803-9.

 Chemical & Physical Properties

Molecular Formula C26H18N6O
Molecular Weight 430.46100
Exact Mass 430.15400
PSA 106.49000
LogP 5.95358

 Synonyms

SR-9186
N-(4'-Cyano[1,1'-biphenyl]-4-yl)-N'-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl] Urea