Nek2 inhibitor (R)-21
Modify Date: 2024-01-09 08:27:31
Nek2 inhibitor (R)-21 structure
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Common Name | Nek2 inhibitor (R)-21 | ||
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| CAS Number | 1364269-10-2 | Molecular Weight | 490.545 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25F3N4O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nek2 inhibitor (R)-21A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2; also shows >100-fold selectivity over a panel of 24 kinases; down-regulates C-Nap1 phosphoryation with IC50 of 0.8 uM, shows antiproliferative effect on U2OS, MDA-MB-231, HeLa and MCF7 cell with GI50 of 1.82, 4.16, 0.59 and 2.17 uM, respectively; is a valuable tool for investigating the role of Nek2 in the cell cycle and its function in mitotic organization. |
| Name | Nek2 inhibitor (R)-21 |
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| Description | A potent and selective NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 22 nM, >200-fold selectivity over Plk1, Mps1, Aurora A and CDK2; also shows >100-fold selectivity over a panel of 24 kinases; down-regulates C-Nap1 phosphoryation with IC50 of 0.8 uM, shows antiproliferative effect on U2OS, MDA-MB-231, HeLa and MCF7 cell with GI50 of 1.82, 4.16, 0.59 and 2.17 uM, respectively; is a valuable tool for investigating the role of Nek2 in the cell cycle and its function in mitotic organization. |
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| References | References 1. Innocenti P, et al. J Med Chem. 2012 Apr 12;55(7):3228-41. View Related Products by Target Hec1/Nek2 |
| Molecular Formula | C24H25F3N4O2S |
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| Molecular Weight | 490.545 |