HIV-1 inhibitor-21

Modify Date: 2024-01-04 17:22:17

HIV-1 inhibitor-21 Structure
HIV-1 inhibitor-21 structure
Common Name HIV-1 inhibitor-21
CAS Number 2554620-04-9 Molecular Weight 476.53
Density N/A Boiling Point N/A
Molecular Formula C28H24N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-21


HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].

 Names

Name HIV-1 inhibitor-21

 HIV-1 inhibitor-21 Biological Activity

Description HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].
Related Catalog
Target

HIV-1 (WT):12.7 nM (EC50)

HIV-1 (K103N):10.4 nM (EC50)

References

[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

 Chemical & Physical Properties

Molecular Formula C28H24N6O2
Molecular Weight 476.53