331261-50-8
331261-50-8 structure
- Name: HIV-1 inhibitor 18A
- Chemical Name: (2E)-N-(2,1,3-Benzothiadiazol-4-yl)-2-(4-hydroxybenzylidene)hydrazinecarboxamide
- CAS Number: 331261-50-8
- Molecular Formula: C14H11N5O2S
- Molecular Weight: 313.334
- Create Date: 2020-01-11 21:22:07
- Modify Date: 2024-01-05 21:28:43
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HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding.
| Name | (2E)-N-(2,1,3-Benzothiadiazol-4-yl)-2-(4-hydroxybenzylidene)hydrazinecarboxamide |
|---|---|
| Synonyms |
(2E)-N-(2,1,3-Benzothiadiazol-4-yl)-2-(4-hydroxybenzylidene)hydrazinecarboxamide
MFCD00617448 Hydrazinecarboxamide, N-2,1,3-benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-, (2E)- |
| Description | HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM; inhibits the CD4-induced disruption of quaternary structures at the trimer apex and the exposure of the gp41 HR1 coiled coil, does not interfere with CD4 or CCR5 binding. |
|---|---|
| References | References 1. Herschhorn A, et al. Nat Chem Biol. 2014 Oct;10(10):845-52. 2. Berinyuy E, et al. J Recept Signal Transduct Res. 2016;36(2):119-29. View Related Products by Target HIV |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H11N5O2S |
| Molecular Weight | 313.334 |
| Exact Mass | 313.063354 |
| LogP | 3.04 |
| Index of Refraction | 1.758 |