137448-39-6

137448-39-6 structure

Name: HIV-1 inhibitor-47
Chemical Name: 2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine
CAS Number: 137448-39-6
Molecular Formula: C₁₂H₁₄N₆
Molecular Weight: 242.28
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-09-25 10:18:39
Modify Date: 2024-04-08 16:14:48
HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].

Name	2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine
Synonyms	MFCD06371724

Description	HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect[1][2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV (Vif-dependent degradation of human APOBEC3G)[1]
In Vitro	APOBEC3G (A3G), a host cytidine deaminase that can block HIV-1 replication and shows antiviral activity. However HIV-1 develops the ability to hijack the cellular ubiquitin/proteasome degradation pathway[1]. HIV-1 inhibitor-47 targets APOBEC3G-apolipoprotein B mRNA editing enzyme catalytic subunit 3G (human), and works on the HIV-1 Vif-APOBEC3G interaction[2].
References	[1]. Iwatani Y, et al. HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19539-44. [2]. Becker Irwin. Preparation of derivatives of 1-(2-pyrimidinyl)piperazine as potential antianxiety, antidepressant, and antipsychotic agents. Journal of Heterocyclic Chemistry. 2008;45(4):1005-1022. [3]. Pubchem: 2-(4-(Pyrazin-2-yl)piperazin-1-yl)pyrimidine-BioAssay Results.