YH 239-EE
Modify Date: 2024-01-31 11:43:06
YH 239-EE structure
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Common Name | YH 239-EE | ||
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| CAS Number | 1364488-67-4 | Molecular Weight | 504.406 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 763.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C25H27Cl2N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 415.4±32.9 °C | |
Use of YH 239-EEYH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agentIC50 value:Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). |
| Name | 1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester |
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| Synonym | More Synonyms |
| Description | YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agentIC50 value:Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 763.3±60.0 °C at 760 mmHg |
| Molecular Formula | C25H27Cl2N3O4 |
| Molecular Weight | 504.406 |
| Flash Point | 415.4±32.9 °C |
| Exact Mass | 503.137848 |
| PSA | 91.50000 |
| LogP | 4.85 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Storage condition | -20℃ |
| Ethyl 6-chloro-3-{1-[(4-chlorobenzyl)(formyl)amino]-2-[(2-methyl-2-propanyl)amino]-2-oxoethyl}-1H-indole-2-carboxylate |
| 1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester |
| YH239-EE |