RP 70676
Modify Date: 2024-01-28 12:52:55
RP 70676 structure
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Common Name | RP 70676 | ||
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| CAS Number | 136609-26-2 | Molecular Weight | 416.582 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 605.9±57.0 °C at 760 mmHg | |
| Molecular Formula | C25H28N4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 320.2±32.1 °C | |
Use of RP 70676RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT. |
| Name | RP 70676 |
|---|---|
| Synonym | More Synonyms |
| Description | RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT. |
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| Related Catalog | |
| Target |
IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)[1] |
| In Vitro | RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM. |
| In Vivo | RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 605.9±57.0 °C at 760 mmHg |
| Molecular Formula | C25H28N4S |
| Molecular Weight | 416.582 |
| Flash Point | 320.2±32.1 °C |
| Exact Mass | 416.203461 |
| LogP | 5.94 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.634 |
| Storage condition | 2-8℃ |
| 1H-Pyrazole, 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl- |
| 1-{5-[(4,5-Diphenyl-1H-imidazol-2-yl)sulfanyl]pentyl}-3,5-dimethyl-1H-pyrazole |