HIV-1 Nef-IN-1

Modify Date: 2024-01-11 05:30:57

Use of HIV-1 Nef-IN-1

HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a Kd of 6.7 μM[1].

Name	4-phenanthren-3-ylbutanoic acid
Synonym	More Synonyms

Description	HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a Kd of 6.7 μM[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 Nef:6.7 μM (Kd)
In Vitro	HIV-1 Nef-IN-1 (Compound D11; 20 μM) inhibits cell viability of COS7 cells, and the cell inhibition rate is 63.2%[1].
References	[1]. Stéphane Betzi, et al. Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19256-61.

HS Code	2916399090

Phenanthrene

CAS#:85-01-8

HIV-1 Nef-IN-1

CAS#:13728-56-8

Literature: Newman,M.S. et al. Journal of Organic Chemistry, 1966 , vol. 31, p. 4293 - 4296

Precursor 1
CAS#:85-01-8 Phenanthrene
DownStream 4
CAS#:13728-58-0 Benz[a]anthrace... CAS#:13728-49-9 1-Cholanthrenone CAS#:202-33-5 benzo[j]aceanth... CAS#:5472-20-8 Benz[a]anthrace...

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

3-Phenanthrenebutanoicacid

3-Phenanthrenebutyric acid

Compound D11

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